The Discovery Studio User Guide is available from the Help menu within the application. A PDF version of the User Guide is also present here: https://community.accelrys.com/docs/DOC-1332
Please note that you must be associated with an account that has an active license for Discovery Studio in order to access the PDF document. Contact Accelrys Support (firstname.lastname@example.org) if you have trouble accessing the document. Contact your account manager if your support agreement is expired and you'd like to renew it so you can access this and other product documents and to obtain product support.